Resources Related to Prescribing Drugs of Dependence

A work in progress written and illustrated by Sam Ioannidis

A new brief opioid stigma scale to assess perceived public attitudes and internalized stigma: Evidence for construct validity

The Challenges of the Inherited Pain Patient on Polypharmacy - Part 1

This video delivers a dark warning related to the management of an inherited chronic pain patient. Drs Gourlay and Heit are dressed appropriately in black suits. Dr Heit: "The first person you take a history and physical when the patient comes in is yourself ...The first person you take a pulse of is your own". Part 2 here


The Neuroscience of Addiction - with Marc Lewis

Although most of this video is technical and discusses various parts of the brain, there are some important points that I find useful in understanding the drug addicted person. There is a reduction in the connection of the part of the brain responsible for control to that responsible for impulses when cues are around. Marc Lewis points out that "Just say NO!" doesn't work and talks about reappraisal.


The Brain and Recovery: An Update on the Neuroscience of Addiction

Dr Kevin McCauley has a personal history of oxycodone addiction. I found it useful to listen to his description of how it felt like to have cravings.


How to Say ‘No!’ to Drug Seekers: A Conversation with Dr Nick Carr

I found this story one of the more useful on the topic of  how to say no. I like the idea of putting a sign on the window stating ‘The doctors in this practice prefer not to prescribe drugs of addiction, such as…’.


The Drug-Seeking Patient in the Emergency Room George R. Hansen, MD
Although published in 2005, this is an excellent, concise and useful review of opioids, addiction, drug seeking and management strategies.


RACGP: Prescribing drugs of dependence in general practice, Part B Benzodiazepines

Quite a comprehensive guide to prescribing benzodiazepines based on the available evidence at the time. The one paragraph I found particularly useful:

"Benzodiazepines have evidence of benefit for GAD, social anxiety disorder and panic disorder, but not for OCD or PTSD[64,94]. Trials have been conducted with clonazepam, diazepam and lorazepam, which have demonstrated the efficacy of these compounds in managing panic disorder clonazepam for SAD, diazepam and bromazepam for GAD[3]"



Long‐term opioid management for chronic noncancer pain

Cochrane Systematic Review - Intervention Version published: 20 January 2010
There is generally no strong evidence for the use of opioids from chronic noncancer pain. According to this Cochrane review there is some weak evidence for use of opioids in this group.


How to Say No to Unreasonable Patient Requests

Dr Girgis's approach is short and complete "Just say no... Explain why... Offer alternatives... Don't argue... Be kind... Be consistent... Understand why a patient is making a request... Set policies up front"


Three persistent myths about heroin use and overdose deaths (Professor Shane Darke's blog)

"What does kill heroin users is polydrug use. More specifically, the use of heroin with other central nervous system depressants, such as alcohol and the benzodiazepines."


Opioid Treatment Agreement (Hunter Integrated Pain Service)

This treatment agreements starts by listed potential benefits and potential problems. It appears to be a great tool for reducing expectations of opoiod treatment and setting up realistic goals. My favorite line is:

 ". . . the expected reduction of chronic pain is only about 20% at the beginning of the treatment period."




Opioid Risk Tool


To assess risk of aberrant behaviors in general practice before starting opioids for chronic pain.

Access to Pain Management - a Fundamental Human Right (Pain Australia)

"Management of acute pain is inadequate for more than 50 percent of people in developed countries and 90 percent of people in developing countries, while chronic non-cancer pain occurs in at least one in five people worldwide, including Australia."



Pain in Residential Aged Care Facilities - Management Strategies
"Research shows that unrecognised and untreated pain, especially non-cancer pain, is widespread among aged care residents. Because many residents have impaired cognition,more than 40 per cent of the Australian nursing home (high-level residential care) population is unable to even report pain."

"The Abbey Pain Scale is recommended as a useful standard pain assessment tool for residents with severe cognitive impairment."  Abbey pain scale

Page 19 shows the "Sterotypic Pain Face".



Naloxone: What should GPs know?

Dr Paul Grinzi answers questions related use of naloxone in the community setting for preventing opioid overdose. I found the most important statement was:

"I would prescribe it for any patient or family member who requests it, and any patient who:
  • is prescribed more than 100 mg oral morphine daily equivalent
  • has a previous history of overdose or near-overdose
  • is prescribed methadone, or other opioids in conjunction with benzodiazepines
  • is experiencing any other circumstances in which I feel there is an increased risk of opioid overdose."



Understanding Australia's new opioid overdose rescue treatment(TGA)

Nyxoid nasal spray is a new emergency treatment for opioid overdose available over the counter.

Information sheet on opioid overdose(WHO)

This information sheet has a list of risk factors for opioid overdose. The following I found the most frightening. When a dependent person has gone without opioids for some time and has regained tolerance then the lethal dose is low.
"People at higher risk of opioid overdose
  • people with opioid dependence, in particular following reduced tolerance (following detoxification, release from incarceration, cessation of treatment);"



AJP.com.au News: Forced tapering and cessation: opioid consequences

This news article communicates some messages from the FDA against sudden withdrawal of opioid pain medicine. We also hear from Pain Australia and Chronic Pain Australia regarding Australia's response to opioid prescribing and the now "... general reluctance across the medical community to prescribe opioids, ...".

Landmark Lancet series reveals poor management of surgery pain key contributor to global opioid crisis
"... it is possible to detect those patients whose pain is “transitioning” from acute to chronic ... The transitioning phase is distinctive from the post-surgical pain and can include sensations like burning, hyper-sensitivity to pain, and itching, all symptoms that can be used as hallmarks for early intervention."

Tapering Long-term Opioid Therapy in Chronic Noncancer Pain (Mayo Clinic Proceedings)

This article covers many aspects of taper management including indications for tapering of long-term opioid treatment, withdrawal issues and management of these issues, taper speed, taper failure, psychological management and management of medicolegal risks. It also deals with alternatives to tapering. There is extensive reference to the quality of evidence taken into account in making recommendations.

How Frequently are “Classic” Drug-Seeking Behaviors Used by Drug-Seeking Patients in the Emergency Department?

This study looked at how frequently "classic" drug seeking behaviours such as 10+ pain, lost/stolen medication, back pain, request medication by name presented to the emergency department and concludes:

"Drug-seeking patients appear to exhibit “classically” described drug-seeking behaviors with only low to moderate frequency, with each of the studied behaviors in this study being recorded as present in less than one third of all ED visits"


A Neurologist’s Guide to Acute Migraine Therapy in the Emergency Room

"Opioids may also render acute migraine medications, such as triptans, less effective and may impair the effectiveness of migraine preventives. ... opioids have the potential to promote chronic migraine and probably medication overuse headache."

"It may be reasonable to consider opioid use for pregnant patients who are refractory to first-line migraine therapies such as fluids and antiemetics, as nonsteroidal anti-inflammatory drugs (NSAIDs) can only be used in certain trimesters of pregnancy, ergots are contraindicated, and in general triptans are contraindicated."